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Scientific Publications

Explore the science and clinical evidence behind Hilo’s technology.
The quest for blood pressure markers in photoplethysmography and its applications in digital health.

Solà J, Arderiu A, Almeida TP, Fallet S, Yazdani S, Haddad S, Perruchoud D, Grossenbacher O, Shah J.

Frontiers in Digital Health. 2025;7:1518322. DOI: 10.3389/fdgth.2025.1518322

Continual Versus Occasional Blood Pressure (COOL-BP) in Remote Hypertension Management.


Unlu O, Cannon CP, Lee S, Gabovitch D, Zelle D, Chin N, Figueroa C, Collins E, Ruggiero R, Almeida TP, Perruchoud D, Solà J, Scirica BM, Fisher NDL.

American Journal of Hypertension. 2025;38(5):295–302. DOI: 10.1093/ajh/hpaf003

Evaluation of Aktiia cuffless blood pressure monitor across 24-h, daytime, and night-time measurements versus ambulatory monitoring: a prospective, single-centre observational study.

Almeida TP, Perruchoud D, Alexandre J, Vermare P, Solà J, Shah J, Marques L, Pellaton C.  

Journal of Hypertension. 2025;43(4):690–697. DOI: 10.1097/HJH.0000000000003960

Hourly Engagement Patterns of a Wearable Monitor Unveil Key Attention Windows for Hypertension Management Strategies.

Almeida TP, Perruchoud D, Zahnd J, Solà J, Shah J, Wuerzner G.  

JACC: Advances. 2025;4(1):101384. DOI: 10.1016/j.jacadv.2024.101384

Optimizing time-in-target-range assessment for blood pressure: insights from a large-scale study with continual cuffless monitoring.

Fisher NDL, Almeida TP, Perruchoud D, Shah J, Solà J.

Frontiers in Medicine. 2024;11:1396962. DOI: 10.3389/fmed.2024.1396962

Performance of the Aktiia optical blood pressure measurement device in the elderly: a comparison with double blinded auscultation in different body positions.

Theiler K, Solà J, Damianaki A, Pfister A, Almeida TP, Alexandre J, Vermare P, Wuerzner G.  

Blood Pressure. 2023;32(1):2281320. DOI: 10.1080/08037051.2023.2281320

The future of blood pressure monitoring: what's next?

Almeida TP, Perruchoud D, Vermare P, Solà J, Shah J, Marques L, Pellaton C.

Hypertension Research. 2023;46:2254–2255.

DOI: 10.1038/s41440-023-01370-3

Inadequate study designs for the evaluation of blood pressure monitoring devices and their potential misleading conclusions.

Almeida TP, Perruchoud D, Shah J, Solà J.

Journal of Hypertension. 2023;41(8):1348–1349.

DOI: 10.1097/HJH.0000000000003458

Aktiia cuffless blood pressure monitor yields equivalent daytime blood pressure measurements compared to a 24-h ambulatory blood pressure monitor: Preliminary results from a prospective single-center study.

Almeida TP, Cortés M, Perruchoud D, Alexandre J, Vermare P, Solà J, Shah J, Marques L, Pellaton C.

A Hypertension Research. 2023;46:1456–1461.

DOI: 10.1038/s41440-023-01258-2

Validation of the Aktiia blood pressure cuff for clinical use according to the ANSI/AAMI/ISO 81060-2:2013 protocol.

Alexandre J, Tan K, Almeida TP, Solà J, Alpert BS, Shah J.

Blood Pressure Monitoring. 2023;28(2):109–112.

DOI: 10.1097/MBP.0000000000000639

Guidance for the Interpretation of Continual Cuffless Blood Pressure Data for the Diagnosis and Management of Hypertension

Solà J, Cortes M, Perruchoud D, De Marco B, Lobo MD, Pellaton C, Wuerzner G, Fisher NDL, Shah J. .

Frontiers in Medical Technology. 2022;4:899143. DOI: 10.3389/fmedt.2022.899143

Monitoring the Personalized Effects of Antihypertensive Drugs Using the Aktiia Optical Device A 4-Month Follow-Up.

Solà J, Fallet S, Wuerzner G. :

Cardiovascular Medicine. 2022;25(2):2152.

DOI: 10.4414/cvm.2022.02152

Validation of the optical Aktiia bracelet in different body positions for the persistent monitoring of blood pressure.

Solà J, Vybornova A, Fallet S, Polychronopoulou E, Wurzner-Ghajarzadeh A, Wuerzner G.

Scientific Reports. 2021;11:20644.

DOI: 10.1038/s41598-021-99294-w

Blood pressure from the optical Aktiia Bracelet: a 1-month validation study using an extended ISO81060-2 protocol adapted for a cuffless wrist device.

Vybornova A, Polychronopoulou E, Wurzner-Ghajarzadeh A, Fallet S, Solà J, Wuerzner G.

Blood Pressure Monitoring. 2021;26(4):305–311.

DOI: 10.1097/MBP.0000000000000531

Is auscultation an issue when validating 24-h blood pressure monitoring devices? Blood Pressure Monitoring.

Wuerzner G, Vybornova A, Wurzner-Ghajarzadeh A, Polychronopoulou E, Fallet S, Solà J, et al.

2020;25(5):301–302.

DOI: 10.1097/MBP.0000000000000462

Accuracy testing of a new optical device for noninvasive estimation of systolic and diastolic blood pressure compared to intra-arterial measurements. Blood Pressure Monitoring.

Pellaton C, Vybornova A, Fallet S, Marques L, Grossenbacher O, De Marco B, Chapuis V, Bertschi M, Alpert BS, Solà J.  

2020;25(2):105–109.

DOI: 10.1097/MBP.0000000000000421

Measuring Pressure: Introducing oBPM, the Optical Revolution for Blood Pressure Monitoring.

Solà J, Bertschi M, Krauss J.  

IEEE Pulse. 2018;9(5):31–33.

DOI: 10.1109/MPUL.2018.2856960